分类: 光学 >> 量子光学 提交时间: 2023-02-19
摘要: Biomarker detection is the key to identifying health risks. However, designing sensitive biosensors in a single-use mode for disease diagnosis remains a major challenge. Here, we report sub-monolayer biolasers with remarkable repeatability for ultrasensitive and disposable biomarker detection. The biolaser sensors are designed by employing the telecom optical fibers as distributed optical microcavities and pushing the gain molecules down to the sub-monolayer level. We observe a status transition from the monolayer biolaser to the sub-monolayer biolaser by tuning the specific conjugation. By reducing the fluorophores down to the threshold density (~ 3.2 x 10-13 mol/cm2), we demonstrate an ultimate sensitivity of sub-monolayer biolaser with six orders of magnitude enhancement compared with the monolayer biolasers. We further achieved ultrasensitive immunoassay for Parkinson's disease biomarker, alpha-synuclein, with a lower limit of detection of 0.32 pM in serum. This biosensor with massive fabrication capability at ultralow cost provides a general method for the ultrasensitive disposable biodetection of disease biomarkers.
分类: 光学 >> 量子光学 提交时间: 2023-02-19
摘要: There exists the phase ambiguity problem in the coherent beam combining (CBC) system with centrosymmetric arrays, which means that multiple different piston aberrations may generate the same far-field image. This will cause that the far-field image can not correctly reflect the phase information, resulting in the performance degradation of image-based intelligent algorithms. In this paper, we make a theoretical analysis on phase ambiguity. To the best of our knowledge, we give the number and descriptions of all solutions of the phase ambiguity problem in above system for the first time. A method to solve phase ambiguity is proposed, which requires no additional optical devices. We designed simulations to verify our conclusions and methods. We believe that our work solves the phase ambiguity problem in theory and is conducive to improving the performance of image-based algorithms. In addition, we designed a two-stage algorithm to generate Bi-beam, which have valuables application in laser propagation.